Pub. Date : 1991 Oct 15
PMID : 1655252
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | L1210-B73 cells, variants of L1210 cells grown in medium containing nanomolar concentrations of folates, express a membrane associated folate binding protein (mFBP) in addition to the classical reduced folate/methotrexate carrier (RF/MTX-carrier) present in L1210 cells grown in standard high folate medium (G. Jansen et al., Cancer Res., 49: 1959-1963, 1989). | Folic Acid | far upstream element (FUSE) binding protein 1 | Mus musculus |
| 2 | L1210-B73 cells, variants of L1210 cells grown in medium containing nanomolar concentrations of folates, express a membrane associated folate binding protein (mFBP) in addition to the classical reduced folate/methotrexate carrier (RF/MTX-carrier) present in L1210 cells grown in standard high folate medium (G. Jansen et al., Cancer Res., 49: 1959-1963, 1989). | Folic Acid | far upstream element (FUSE) binding protein 1 | Mus musculus |
| 3 | L1210-B73 cells, variants of L1210 cells grown in medium containing nanomolar concentrations of folates, express a membrane associated folate binding protein (mFBP) in addition to the classical reduced folate/methotrexate carrier (RF/MTX-carrier) present in L1210 cells grown in standard high folate medium (G. Jansen et al., Cancer Res., 49: 1959-1963, 1989). | Folic Acid | far upstream element (FUSE) binding protein 1 | Mus musculus |
| 4 | L1210-B73 cells, variants of L1210 cells grown in medium containing nanomolar concentrations of folates, express a membrane associated folate binding protein (mFBP) in addition to the classical reduced folate/methotrexate carrier (RF/MTX-carrier) present in L1210 cells grown in standard high folate medium (G. Jansen et al., Cancer Res., 49: 1959-1963, 1989). | Folic Acid | far upstream element (FUSE) binding protein 1 | Mus musculus |
| 5 | In this study we used L1210-B73 and L1210 cells as a model system to study the affinity of the RF/MTX-carrier and the mFBP for the natural folate compounds folic acid and 5-formyltetrahydrofolate (5-CHO-THF), as well as a number of antifolate compounds. | Folic Acid | far upstream element (FUSE) binding protein 1 | Mus musculus |
| 6 | In this study we used L1210-B73 and L1210 cells as a model system to study the affinity of the RF/MTX-carrier and the mFBP for the natural folate compounds folic acid and 5-formyltetrahydrofolate (5-CHO-THF), as well as a number of antifolate compounds. | Folic Acid | far upstream element (FUSE) binding protein 1 | Mus musculus |
| 7 | Binding affinities of the mFBP decreased in the order CB3717 greater than or equal to folic acid = ICI-198,583 greater than or equal to 5-CHO-THF much greater than MTX = 10-EdAM. | Folic Acid | far upstream element (FUSE) binding protein 1 | Mus musculus |
| 8 | Over 24 h, at 25 nM, [3H]folic acid uptake in L1210-B73 cells was found to proceed for more than 98% via the mFBP. | Folic Acid | far upstream element (FUSE) binding protein 1 | Mus musculus |