Title : Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2.

Pub. Date : 2006 May 26

PMID : 16551619






1 Functional Relationships(s)
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1 Pharmacological inhibitors (LiCl and PDZD-8) and genetic variants of GSK-3beta (constitutively active and dominant negative mutants) indicated that PI3K/Akt activates and GSK-3beta inhibits the antioxidant response elements of the ho1 promoter and pointed Nrf2 as directly involved in this process. Lithium Chloride AKT serine/threonine kinase 1 Homo sapiens