Title : Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase.

Pub. Date : 2006 Mar

PMID : 16546977






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1 We found that the naphthoquinone spiroketal fungal metabolite palmarumycin CP1 is a potent inhibitor of thioredoxin reductase-1, but attempts to exploit the activity of palmarumycin CP1 analogues as antitumor agents in vivo were hampered by their insolubility. Naphthoquinones thioredoxin reductase 1 Homo sapiens