Pub. Date : 2006 Mar
PMID : 16546974
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential effects of bryostatin 1 and 12-O-tetradecanoylphorbol-13-acetate on the regulation and activation of RasGRP1 in mouse epidermal keratinocytes. | Tetradecanoylphorbol Acetate | RAS guanyl releasing protein 1 | Mus musculus |
| 2 | We recently reported that the novel DAG receptor RasGRP1 is expressed in mouse keratinocytes and mediates TPA-induced Ras activation. | Tetradecanoylphorbol Acetate | RAS guanyl releasing protein 1 | Mus musculus |
| 3 | We found that whereas TPA induced translocation of RasGRP1 to both the plasma and internal membranes of the keratinocytes, bryostatin 1 recruited RasGRP1 only to internal membranes and the nuclear envelope. | Tetradecanoylphorbol Acetate | RAS guanyl releasing protein 1 | Mus musculus |
| 4 | In addition, TPA led to a concentration-dependent down-regulation of RasGRP1, whereas bryostatin 1 failed to induce full RasGRP1 down-regulation. | Tetradecanoylphorbol Acetate | RAS guanyl releasing protein 1 | Mus musculus |