Title : Effect of heme and heme oxygenase-1 on vascular endothelial growth factor synthesis and angiogenic potency of human keratinocytes.

Pub. Date : 2006 Apr 1

PMID : 16545694






3 Functional Relationships(s)
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1 RESULTS: Treatment of HaCaT keratinocytes with hemin (heme chloride) induced HO-1 expression and activity. Hemin heme oxygenase 1 Homo sapiens
2 Moreover, HO-1 expression was also induced in keratinocytes cultured in hypoxia, with concomitant augmentation of VEGF production, which was further potentiated by hemin stimulation. Hemin heme oxygenase 1 Homo sapiens
3 CONCLUSIONS: HO-1 is involved in hemin-induced VEGF expression in HaCaT and may play a role in hypoxic regulation of this protein. Hemin heme oxygenase 1 Homo sapiens