Title : CD40L induces multidrug resistance to apoptosis in breast carcinoma and lymphoma cells through caspase independent and dependent pathways.

Pub. Date : 2006 Mar 18

PMID : 16545138






2 Functional Relationships(s)
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1 Co culture with CD40L L cells also blocked the apoptosis induced by exogenous ceramides in breast carcinoma and non Hodgkin"s lymphoma cell lines through a caspase-3-like, 8-like and 9-like dependent pathways. Ceramides CD40 ligand Homo sapiens
2 CONCLUSION: These results indicate that CD40L expressed on adjacent non tumoral cells induces multidrug resistance to cytotoxic agents and ceramides in both breast carcinoma and non Hodgkin"s lymphoma cell lines, albeit through a caspase independent and dependent pathway respectively. Ceramides CD40 ligand Homo sapiens