Pub. Date : 2006 Apr
PMID : 16543948
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | First, zymosan induces DCs to secrete abundant IL-10 but little IL-6 and IL-12(p70). | Zymosan | interleukin 10 | Mus musculus |
| 2 | Consistent with these effects on APCs, injection of zymosan plus OVA into mice results in OVA-specific T cells that secrete little or no Th1 or Th2 cytokines, but secrete robust levels of IL-10, and are unresponsive to challenge with OVA plus adjuvant. | Zymosan | interleukin 10 | Mus musculus |
| 3 | Finally, coinjection of zymosan with OVA plus LPS suppresses the response to OVA via a mechanism dependent on IL-10, TGF-beta, and lack of IL-6. | Zymosan | interleukin 10 | Mus musculus |
| 4 | Together, our data demonstrate that zymosan stimulates IL-10+ IL-12(p70)- IL-6low regulatory DCs and TGF-beta+ macrophages to induce immunological tolerance. | Zymosan | interleukin 10 | Mus musculus |