Title : Differential regulation of protooncogenes c-jun and jun D expressions by protein tyrosine kinase, protein kinase C, and cyclic-AMP mitogenic pathways in dog primary thyrocytes: TSH and cyclic-AMP induce proliferation but downregulate C-jun expression.

Pub. Date : 1991 Oct

PMID : 1654270






2 Functional Relationships(s)
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1 Increasing intracellular concentrations of cyclic-AMP by forskolin or TSH was followed by an inhibition of the expression of c-jun. Colforsin Jun proto-oncogene, AP-1 transcription factor subunit Canis lupus familiaris
2 Similarly, the TPA or EGF stimulation of c-jun expression was also inhibited by TSH or forskolin, as in fibroblasts in which cyclic-AMP inhibits proliferation. Colforsin Jun proto-oncogene, AP-1 transcription factor subunit Canis lupus familiaris