Pub. Date : 2005
PMID : 16541750
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Since cyclosporine is a substrate and inhibitor of CYP3A4, researchers suspect that the immunosuppressant inhibits CYP3A4-mediated metabolism of statins, leading to an increase in statin plasma concentration and infrequently resulting in rhabdomyolysis. | Cyclosporine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Since cyclosporine is a substrate and inhibitor of CYP3A4, researchers suspect that the immunosuppressant inhibits CYP3A4-mediated metabolism of statins, leading to an increase in statin plasma concentration and infrequently resulting in rhabdomyolysis. | Cyclosporine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Furthermore, in the Japanese package inserts, it is either stated that cyclosporine inhibits CYP3A4-mediated metabolism or no comment is made on the mechanism. | Cyclosporine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |