Title : [Effect on apoptosis of anterior pituitary induced by cadmium chloride and its relations with p38 MAPK & ERK1/2 passway].

Pub. Date : 2005 Nov

PMID : 16535835






1 Functional Relationships(s)
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1 RESULTS: The results showed that the apoptosis induced by CdCl2 inclined to enhance with dose dependent manner, Further more, U0126 and SB203580, the specific inhibitor of ERK1/2 and p38 MAPK respectively, could decrease the expression of TUNEL-positive cells significantly and lower apoptotic rate of primary cultured anterior pituitary cells. U 0126 mitogen activated protein kinase 14 Rattus norvegicus