Title : Microbial Demethylation of Immunosuppressant FK-506: Isolation of 31-O-FK-506-Specific Demethylase Showing Cytochrome P-450 Characteristics from Streptomyces rimosus MA187.

Pub. Date : 1995 Oct

PMID : 16535142






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The enzyme responsible for this demethylation (31-O-FK-506 demethylase) was isolated and shown to be a soluble cytoplasmic protein which is constitutively expressed in the cells, which requires NADPH, ferredoxin-NADP(sup+)-reductase, and ferredoxin for activity, and which shows a cytochrome P-450 light absorption characteristic. NADP cytochrome P450 family 4 subfamily F member 3 Homo sapiens