Title : Microbial Demethylation of Immunosuppressant FK-506: Isolation of 31-O-FK-506-Specific Demethylase Showing Cytochrome P-450 Characteristics from Streptomyces rimosus MA187.

Pub. Date : 1995 Oct

PMID : 16535142






1 Functional Relationships(s)
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1 Carbon monoxide saturation of the enzyme preparation and known mammalian cytochrome P-450 inhibitors such as quinidine HCl, ketoconazole, troleandomycin, and sulfaphenazole abolish the demethylating activity extensively. Ketoconazole cytochrome P450 family 4 subfamily F member 3 Homo sapiens