Title : RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells.

Pub. Date : 2006 Feb 21

PMID : 16533754






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Finally, we found that c-Kit internalization was delayed in the absence of RabGEF1, probably reflecting a positive role for RabGEF1 in the regulation of endocytic events, and that infection of Rabgef1-/- BMCMCs with a wild-type RabGEF1 lentiviral construct normalized c-Kit internalization to the levels seen in +/+ BMCMCs. bmcmcs KIT proto-oncogene receptor tyrosine kinase Mus musculus
2 Finally, we found that c-Kit internalization was delayed in the absence of RabGEF1, probably reflecting a positive role for RabGEF1 in the regulation of endocytic events, and that infection of Rabgef1-/- BMCMCs with a wild-type RabGEF1 lentiviral construct normalized c-Kit internalization to the levels seen in +/+ BMCMCs. bmcmcs KIT proto-oncogene receptor tyrosine kinase Mus musculus
3 Finally, we found that c-Kit internalization was delayed in the absence of RabGEF1, probably reflecting a positive role for RabGEF1 in the regulation of endocytic events, and that infection of Rabgef1-/- BMCMCs with a wild-type RabGEF1 lentiviral construct normalized c-Kit internalization to the levels seen in +/+ BMCMCs. bmcmcs KIT proto-oncogene receptor tyrosine kinase Mus musculus