Title : A murine model for human sepiapterin-reductase deficiency.

Pub. Date : 2006 Apr

PMID : 16532389






2 Functional Relationships(s)
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1 Here, we report that mice deficient in the Spr gene (Spr(-/-)) display disturbed pterin profiles and greatly diminished levels of dopamine, norepinephrine, and serotonin, indicating that SPR is essential for homeostasis of BH(4) and for the normal functions of BH(4)-dependent enzymes. Pterins sepiapterin reductase Mus musculus
2 Here, we report that mice deficient in the Spr gene (Spr(-/-)) display disturbed pterin profiles and greatly diminished levels of dopamine, norepinephrine, and serotonin, indicating that SPR is essential for homeostasis of BH(4) and for the normal functions of BH(4)-dependent enzymes. Pterins sepiapterin reductase Mus musculus