Title : Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin.

Pub. Date : 2006 May

PMID : 16532021






3 Functional Relationships(s)
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1 We also investigated the effect of the flavonol quercetin that was recently shown to strongly inhibit IL-6 secretion in response to allergic stimulation from hCBMCs.IL-1 stimulated p38, but did not activate extracellular signal-regulated kinase (ERK) or c-jun N-terminal kinase (JNK); it also did not activate protein kinase C (PKC) isozymes alpha, beta, mu and zeta, except for PKC-theta, which was phosphorylated. Quercetin interleukin 6 Homo sapiens
2 These results indicate that IL-1-stimulated IL-6 production from human mast cells is regulated by biochemical pathways distinct from IgE-induced degranulation and that quercetin can block both IL-6 secretion and two key signal transduction steps involved. Quercetin interleukin 6 Homo sapiens
3 These results indicate that IL-1-stimulated IL-6 production from human mast cells is regulated by biochemical pathways distinct from IgE-induced degranulation and that quercetin can block both IL-6 secretion and two key signal transduction steps involved. Quercetin interleukin 6 Homo sapiens