Title : Chronic psychosocial stress-induced impairment of hippocampal LTP: possible role of BDNF.

Pub. Date : 2006 Jun

PMID : 16530419






3 Functional Relationships(s)
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1 Immunoblot analysis showed that chronic nicotine treatment (1 mg/kg, 2 times/day) normalized the stress-induced decrease in the basal levels of BDNF, CaMKII (total and phosphorylated; P-CaMKII), and calmodulin. Nicotine brain-derived neurotrophic factor Rattus norvegicus
2 Chronic nicotine treatment also markedly increased the basal levels of BDNF in naive rats. Nicotine brain-derived neurotrophic factor Rattus norvegicus
3 These results indicate that normalization by nicotine of the stress-induced changes in the levels of signaling molecules including BDNF may contribute to the recovery of LTP. Nicotine brain-derived neurotrophic factor Rattus norvegicus