Title : Gene expression of ferredoxin reductase predicts outcome in patients with metastatic colorectal cancer treated by 5-fluorouracil plus leucovorin.

Pub. Date : 2006 Dec

PMID : 16528528






4 Functional Relationships(s)
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1 PURPOSE: Ferredoxin reductase (FDXR) is a putative contributor to p53-mediated apoptosis from 5-fluorouracil (5-FU) through the generation of oxidative stress in the mitochondria. Fluorouracil tumor protein p53 Homo sapiens
2 PURPOSE: Ferredoxin reductase (FDXR) is a putative contributor to p53-mediated apoptosis from 5-fluorouracil (5-FU) through the generation of oxidative stress in the mitochondria. Fluorouracil tumor protein p53 Homo sapiens
3 FDXR gene expression, which is regulated at least in part by p53, is associated with both response and survival when metastatic colorectal cancer is treated with 5-FU plus LV. Fluorouracil tumor protein p53 Homo sapiens
4 In addition, analysis of p53 mutation combined with FDXR gene expression might be useful in estimating the outcome in 5-FU-treated patients. Fluorouracil tumor protein p53 Homo sapiens