Pub. Date : 2006 May
PMID : 16525023
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We demonstrated that the interaction is mediated by the binding of PLC-gamma1 Src homology (SH) 3 domain to Akt proline-rich motifs. | Proline | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | We also provide a novel model to depict how the interaction between PLC-gamma1 SH3 domain and Akt proline-rich motifs is dependent on EGF stimulation. | Proline | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In this model, phosphorylation of PLC-gamma1 Y783 by EGF causes the conformational change of PLC-gamma1 to allow the interaction of its SH3 domain with Akt proline-rich motifs. | Proline | AKT serine/threonine kinase 1 | Homo sapiens |