Title : Analogues of the 5-HT1A serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced alpha 1-adrenergic affinity.

Pub. Date : 1991 Aug

PMID : 1652026






1 Functional Relationships(s)
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1 Replacement of the phthalimide moiety by substituted benzamides led to retention of 5-HT1A affinity but to no improvement in selectivity, whereas replacement by alkyl amides proved beneficial, leading to an improvement in affinity and selectivity. phthalimide 5-hydroxytryptamine receptor 1A Homo sapiens