Title : Epidermal growth factor decreases the concentration of thyrotropin-releasing hormone (TRH) receptors and TRH responses in pituitary GH4C1 cells.

Pub. Date : 1991 Sep

PMID : 1651844






2 Functional Relationships(s)
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1 EGF significantly blunted the ability of TRH to stimulate release of inositol phosphates from metabolically labeled cells. Inositol Phosphates thyrotropin releasing hormone Rattus norvegicus
2 TRH increased inositol monophosphate accumulation 6.3-fold in control cultures and 2.0-fold in EGF-treated cells. Inositol Phosphates thyrotropin releasing hormone Rattus norvegicus