Pub. Date : 2006 Apr 20
PMID : 16518417
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dicoumarol potentiates cisplatin-induced apoptosis mediated by c-Jun N-terminal kinase in p53 wild-type urogenital cancer cell lines. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Furthermore, inhibition of JNK, using SP600125, completely suppressed activity of caspases and poly-(ADP-ribose) polymerase cleavage, leading to suppression of enhancement of CDDP-mediated apoptosis by dicoumarol. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | These results suggested that dicoumarol could enhance cytotoxicity of CDDP in urogenital cancer cells with wild-type p53 through the p53/p21/JNK pathways. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |