Title : Surfactant protein A is opsonin in phagocytosis of herpes simplex virus type 1 by rat alveolar macrophages.

Pub. Date : 1991 Aug

PMID : 1651668






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The phagocytosis of FITC-HSV-1 by alveolar macrophages, which was studied as a model for virus phagocytosis in general, was strongly enhanced in the presence of SP-A. Fluorescein-5-isothiocyanate surfactant protein A1 Homo sapiens
2 The addition of SP-A to the system was sufficient for the phagocytosis of FITC-HSV-1 by the alveolar macrophages, suggesting that SP-A acts as an opsonin. Fluorescein-5-isothiocyanate surfactant protein A1 Homo sapiens
3 The addition of SP-A to the system was sufficient for the phagocytosis of FITC-HSV-1 by the alveolar macrophages, suggesting that SP-A acts as an opsonin. Fluorescein-5-isothiocyanate surfactant protein A1 Homo sapiens
4 This hypothesis was further strengthened by the observation that F(ab")2 fragments of immunoglobulin G directed against SP-A could abolish FITC-HSV-1 phagocytosis by alveolar macrophages preincubated with SP-A. Fluorescein-5-isothiocyanate surfactant protein A1 Homo sapiens
5 Comparing the opsonic capacity of serum and SP-A, SP-A proved to be twice as potent as serum in stimulating phagocytosis of FITC-HSV-1 by alveolar macrophages. Fluorescein-5-isothiocyanate surfactant protein A1 Homo sapiens