Title : Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells.

Pub. Date : 2006 Feb

PMID : 16513842






2 Functional Relationships(s)
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1 In addition, we found that doxorubicin inhibited AR expression, and p21 protein completely disappeared after simultaneous treatment with trichostatin A and doxorubicin. trichostatin A H3 histone pseudogene 16 Homo sapiens
2 The synergistic effect of simultaneous treatment with trichostatin A and doxorubicin is mediated via inhibition of AR expression, induction of protease activity, increased expression of p53, and proteolysis of p21. trichostatin A H3 histone pseudogene 16 Homo sapiens