Pub. Date : 2006 Mar
PMID : 16511915
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. | Simvastatin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | We investigated whether simvastatin could inhibit the expression of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha (TNF-alpha) in fibroblast-like synoviocytes (FLS) obtained from RA patients undergoing joint replacement therapy. | Simvastatin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | RESULTS: Real-time PCR analysis revealed that the levels of IL-6 and IL-8 mRNA expressed by FLS were reduced by simvastatin in a dose-dependent manner. | Simvastatin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | Levels of IL-6 and IL-8 in FLS culture supernatants were decreased by simvastatin in a time-dependent and dose-dependent manner. | Simvastatin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | These effects of simvastatin on IL-6 and IL-8 production and cell proliferation were reversed in the presence of mevalonic acid or geranylgeranyl-pyrophosphate, but not with farnesyl-pyrophosphate. | Simvastatin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 6 | CONCLUSION: Our results suggest that the beneficial effect of simvastatin in RA patients may involve inhibition of IL-6 and IL-8 production, as well as reduction of cell proliferation. | Simvastatin | C-X-C motif chemokine ligand 8 | Homo sapiens |