Title : Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform.

Pub. Date : 2006 Jun

PMID : 16510539






2 Functional Relationships(s)
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Protein Name
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1 UGT1A10 exhibited considerably more glucuronidation activity as determined by Vmax/Km against 3-hydroxy (OH)-BaP, 7-OH-BaP, 9-OH-BaP, and 1-OH-pyrene than any other UGT1A family member. 1-oh-pyrene UDP glucuronosyltransferase family 1 member A10 Homo sapiens
2 Although a kinetic comparison using Vmax could not be performed against family 2B UGTs, UGT1A10 exhibited a 1.7- to 254-fold lower Km than active family 2B UGTs against 3-OH-BaP, 7-OH-BaP, and 1-OH-pyrene. 1-oh-pyrene UDP glucuronosyltransferase family 1 member A10 Homo sapiens