Title : Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.

Pub. Date : 2006 Jul 1

PMID : 16509823






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In the presence of oxygen, they hydroxylate specific proline residues in HIF-alpha, allowing recognition by pVHL (von Hippel-Lindau protein) and subsequent ubiquitylation and proteasomal destruction. Proline von Hippel-Lindau tumor suppressor Homo sapiens