Title : A role for ERK2 in reconsolidation of fear memories in mice.

Pub. Date : 2006 Sep

PMID : 16504549






3 Functional Relationships(s)
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1 In the present study, in order to investigate the involvement of MAPKs in memory reconsolidation processes we administered immediately after retrieval, different doses of SL327 (an inhibitor of MEK, a kinase that activates both ERK1 and ERK2) both in C57BL/6 (C57) mice and ERK1 mutant mice tested in a fear conditioning task. SL 327 mitogen-activated protein kinase 3 Mus musculus
2 In the present study, in order to investigate the involvement of MAPKs in memory reconsolidation processes we administered immediately after retrieval, different doses of SL327 (an inhibitor of MEK, a kinase that activates both ERK1 and ERK2) both in C57BL/6 (C57) mice and ERK1 mutant mice tested in a fear conditioning task. SL 327 mitogen-activated protein kinase 3 Mus musculus
3 Moreover, SL327 administration impaired memory reconsolidation also in ERK1 mutant mice. SL 327 mitogen-activated protein kinase 3 Mus musculus