Title : Curcumin induces heme oxygenase-1 in hepatocytes and is protective in simulated cold preservation and warm reperfusion injury.

Pub. Date : 2006 Feb 27

PMID : 16495813






5 Functional Relationships(s)
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1 This study investigates in detail the effect of curcumin on the stress-response in human hepatocytes, in particular its effect on heme oxygenase 1 (HO-1) and its cytoprotective effect. Curcumin heme oxygenase 1 Homo sapiens
2 This study investigates in detail the effect of curcumin on the stress-response in human hepatocytes, in particular its effect on heme oxygenase 1 (HO-1) and its cytoprotective effect. Curcumin heme oxygenase 1 Homo sapiens
3 Pretreatment with curcumin protected hepatocytes in a model of oxidative injury and this protection was mediated through HO-1. Curcumin heme oxygenase 1 Homo sapiens
4 In a model of cold preservation injury, curcumin pretreatment resulted in elevation of HO-1 throughout the cold storage and rewarming period, and was cytoprotective against oxidative injury. Curcumin heme oxygenase 1 Homo sapiens
5 This is the first study to demonstrate that curcumin induces HO-1 in human hepatocytes, and that the protective effects of curcumin pretreatment may have clinical potential in hepatic transplantation. Curcumin heme oxygenase 1 Homo sapiens