Title : Pipecolic acid-catalyzed direct asymmetric mannich reactions.

Pub. Date : 2006 Mar 2

PMID : 16494447






2 Functional Relationships(s)
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Protein Name
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1 In contrast, (S)-proline-catalyzed reactions give mainly syn-products with high enantioselectivities. Proline synemin Homo sapiens
2 Computational studies reveal that the energetic preference between the transition structures involving the s-cis-enamine and the s-trans-enamine is smaller for the pipecolic acid as compared to proline, yielding the (2S,3R)-anti and the (2S,3S)-syn Mannich product in nearly equal amounts. Proline synemin Homo sapiens