Title : Histamine H1 receptor-stimulated interleukin 8 and granulocyte macrophage colony-stimulating factor production by bronchial epithelial cells requires extracellular signal-regulated kinase signaling via protein kinase C.

Pub. Date : 2006

PMID : 16491014






3 Functional Relationships(s)
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1 Histamine H1 receptor-stimulated interleukin 8 and granulocyte macrophage colony-stimulating factor production by bronchial epithelial cells requires extracellular signal-regulated kinase signaling via protein kinase C. BACKGROUND: Histamine stimulates the release of several cytokines, such as interleukin (IL)-8 and granulocyte macrophage colony-stimulating factor, from bronchial epithelial cells. Histamine C-X-C motif chemokine ligand 8 Homo sapiens
2 Ro-31-8220, a PKC inhibitor, and PD98059, a mitogen-activated protein/ERK kinase inhibitor, suppressed the histamine-induced ERK activation and the production of granulocyte macrophage colony-stimulating factor and IL-8. Histamine C-X-C motif chemokine ligand 8 Homo sapiens
3 Histamine also augmented the IL-8 production caused by IL-4 or tumor necrosis factor-alpha. Histamine C-X-C motif chemokine ligand 8 Homo sapiens