Pub. Date : 2006 Jun 2
PMID : 16489207
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB. | halofuginone | mitogen activated protein kinase 14 | Rattus norvegicus |
| 2 | p38 mitogen-activated protein kinase (p38 MAPK) and nuclear factor kappaB(NFkappaB) pathways were activated by HAL, and specific inhibitors of p38 MAPK and NFkappaB dose dependently inhibited MMP-13 induction. | halofuginone | mitogen activated protein kinase 14 | Rattus norvegicus |
| 3 | p38 mitogen-activated protein kinase (p38 MAPK) and nuclear factor kappaB(NFkappaB) pathways were activated by HAL, and specific inhibitors of p38 MAPK and NFkappaB dose dependently inhibited MMP-13 induction. | halofuginone | mitogen activated protein kinase 14 | Rattus norvegicus |
| 4 | p38 mitogen-activated protein kinase (p38 MAPK) and nuclear factor kappaB(NFkappaB) pathways were activated by HAL, and specific inhibitors of p38 MAPK and NFkappaB dose dependently inhibited MMP-13 induction. | halofuginone | mitogen activated protein kinase 14 | Rattus norvegicus |
| 5 | In conclusion, submicromolar concentrations of HAL inhibit HSC proliferation and migration and up-regulate their expression of fibrolytic MMP-3 and -13 via activation of p38 MAPK and NFkappaB. | halofuginone | mitogen activated protein kinase 14 | Rattus norvegicus |