Title : AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B.

Pub. Date : 2006 Jul

PMID : 16489105






4 Functional Relationships(s)
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1 In this work, we studied the relationship between AMPK activation and glucose uptake stimulation by biguanides and oligomycin, another AMPK activator, in both insulin-sensitive and insulin-resistant cardiomyocytes. Biguanides protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
2 Stimulation of glucose uptake by insulin or biguanides was correlated to protein kinase B (PKB) or AMPK activation, respectively, and were additive. Biguanides protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
3 We concluded that AMPK activators, like biguanides and oligomycin, are able to restore glucose uptake stimulation, in the absence of insulin, in insulin-resistant cardiomyocytes via the additive activation of AMPK and PKB. Biguanides protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
4 We concluded that AMPK activators, like biguanides and oligomycin, are able to restore glucose uptake stimulation, in the absence of insulin, in insulin-resistant cardiomyocytes via the additive activation of AMPK and PKB. Biguanides protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens