Title : Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells.

Pub. Date : 2006 Feb 15

PMID : 16489067






2 Functional Relationships(s)
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1 CONCLUSION: IDO-high expression by colorectal tumor cells enables certain cancer subsets to initially avoid immune attack and defeat the invasion of T cells via local tryptophan depletion and the production of proapoptotic tryptophan catabolites. Tryptophan indoleamine 2,3-dioxygenase 1 Homo sapiens
2 CONCLUSION: IDO-high expression by colorectal tumor cells enables certain cancer subsets to initially avoid immune attack and defeat the invasion of T cells via local tryptophan depletion and the production of proapoptotic tryptophan catabolites. Tryptophan indoleamine 2,3-dioxygenase 1 Homo sapiens