Title : Retinoic acid is a negative regulator of AP-1-responsive genes.

Pub. Date : 1991 Jul 15

PMID : 1648728






2 Functional Relationships(s)
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1 We present evidence that retinoic acid can down-regulate transcriptional activation by the nuclear protooncogene c-jun. Tretinoin Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 These data suggest that the RAR alpha may form a nonproductive complex with c-Jun and provides a simple mechanisms by which retinoic acid may limit cell growth and possibly malignant progression. Tretinoin Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens