Title : Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between celecoxib and aceclofenac.

Pub. Date : 2006 Aug

PMID : 16476713






2 Functional Relationships(s)
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1 These data suggest that PGE(2) blocking agents may decrease PGE(2) production not only by direct COX-2 inhibition but also by down regulating COX-2 expression and synthesis. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 These data suggest that PGE(2) blocking agents may decrease PGE(2) production not only by direct COX-2 inhibition but also by down regulating COX-2 expression and synthesis. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens