Title : Acquired chemoresistance in pancreatic carcinoma cells: induced secretion of IL-1beta and NO lead to inactivation of caspases.

Pub. Date : 2006 Jun 29

PMID : 16474845






2 Functional Relationships(s)
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1 The increased IL-1beta secretion was accompanied by an elevated formation of nitric oxide (NO) and a NO-dependent inhibition of the etoposide-induced caspase-3/-7/-8/-9 activity. Etoposide interleukin 1 beta Homo sapiens
2 Conversely, IL-1beta or the NO-donor SNAP decreased caspase activation and apoptosis in etoposide-treated PT45-P1 cells. Etoposide interleukin 1 beta Homo sapiens