Pub. Date : 2006 Oct
PMID : 16470410
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells. | gambogic acid | telomerase reverse transcriptase | Homo sapiens |
| 2 | Both telomerase activity and hTERT mRNA expression were notably decreased in cells treated with GA. | gambogic acid | telomerase reverse transcriptase | Homo sapiens |
| 3 | The activity of hTERT promoter and the expression of c-MYC were also remarkably decreased in GA-treated cells. | gambogic acid | telomerase reverse transcriptase | Homo sapiens |
| 4 | CONCLUSION: This study demonstrated that GA treatment of human gastric carcinoma cell lines, MGC-803 and SGC-7901, significantly reduced the expression of c-MYC in a time- and concentration-dependent manner accompanied with the down-regulation of the hTERT transcription and the ultimate reduction in telomerase activity. | gambogic acid | telomerase reverse transcriptase | Homo sapiens |