Title : Conformational changes in prorenin during renin inhibition in vitro and in vivo.

Pub. Date : 2006 Mar

PMID : 16467656






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Whether such changes in renin recognition by monoclonal antibodies exist after oral administration of aliskiren, the first orally available renin inhibitor, is not known. aliskiren renin Homo sapiens
2 Whether such changes in renin recognition by monoclonal antibodies exist after oral administration of aliskiren, the first orally available renin inhibitor, is not known. aliskiren renin Homo sapiens
3 RESULTS: The addition of aliskiren to plasma samples in vitro, at concentrations of 1-100 micromol/l, increased active renin immunoreactivity in both the Cisbio and Nichols assays. aliskiren renin Homo sapiens