Title : Calcium ion exchange in crystalline gelsolin.

Pub. Date : 2006 Mar 31

PMID : 16466744






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Calcium ion exchange in crystalline gelsolin. Calcium gelsolin Homo sapiens
2 Gelsolin is a calcium and pH-sensitive modulator of actin filament length. Calcium gelsolin Homo sapiens
3 Here, we use X-ray crystallography to examine the extraction and exchange of calcium ions from their binding sites in different crystalline forms of the activated N and C-terminal halves of gelsolin, G1-G3 and G4-G6, respectively. Calcium gelsolin Homo sapiens
4 However, high-resolution details of changes in the ion-binding sites may represent the initial steps toward restoration of the arrangement of domains found in the calcium-free inactive form of gelsolin in solution. Calcium gelsolin Homo sapiens
5 Furthermore, bathing crystals with the trivalent calcium ion mimic, Tb3+, results in anomalous scattering data that permit unequivocal localization of terbium ions in each of the proposed type I and type II ion-binding sites of both halves of gelsolin. Calcium gelsolin Homo sapiens