Title : Systemic use of argatroban reduces tumor mass, attenuates neurological deficits and prolongs survival time in rat glioma models.

Pub. Date : 2005

PMID : 16463890






2 Functional Relationships(s)
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1 Our previous studies showed that intracerebral infusion of argatroban, a specific thrombin inhibitor, reduces brain edema and neurological deficits in a C6 glioma model. argatroban coagulation factor II Rattus norvegicus
2 These results suggest that thrombin plays a key role in glioma growth and thrombin inhibition with argatroban may be a novel treatment for gliomas. argatroban coagulation factor II Rattus norvegicus