Title : Solution structure of p53 core domain: structural basis for its instability.

Pub. Date : 2006 Feb 14

PMID : 16461916






1 Functional Relationships(s)
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1 We mutated one such buried pair, Tyr-236 and Thr-253 to Phe-236 and Ile-253 (as found in the paralogs p63 and p73), and stabilized p53 by 1.6 kcal/mol. Isoleucine tumor protein p53 Homo sapiens