Title : A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein.

Pub. Date : 2006 Feb 13

PMID : 16461359






8 Functional Relationships(s)
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Protein Name
Organism
1 Reactive oxygen species (ROS) generated by polyQ accumulation triggered the association of CRAG with polyQ and the nuclear translocation of the CRAG-polyQ complex. polyglutamine ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Homo sapiens
2 Reactive oxygen species (ROS) generated by polyQ accumulation triggered the association of CRAG with polyQ and the nuclear translocation of the CRAG-polyQ complex. polyglutamine ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Homo sapiens
3 Reactive oxygen species (ROS) generated by polyQ accumulation triggered the association of CRAG with polyQ and the nuclear translocation of the CRAG-polyQ complex. polyglutamine ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Homo sapiens
4 Reactive oxygen species (ROS) generated by polyQ accumulation triggered the association of CRAG with polyQ and the nuclear translocation of the CRAG-polyQ complex. polyglutamine ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Homo sapiens
5 Reactive oxygen species (ROS) generated by polyQ accumulation triggered the association of CRAG with polyQ and the nuclear translocation of the CRAG-polyQ complex. polyglutamine ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Homo sapiens
6 Reactive oxygen species (ROS) generated by polyQ accumulation triggered the association of CRAG with polyQ and the nuclear translocation of the CRAG-polyQ complex. polyglutamine ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Homo sapiens
7 CRAG knockdown by small interfering RNA in neuronal cells consistently blocked the nuclear translocation of polyQ and enhanced polyQ-mediated cell death. polyglutamine ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Homo sapiens
8 CRAG knockdown by small interfering RNA in neuronal cells consistently blocked the nuclear translocation of polyQ and enhanced polyQ-mediated cell death. polyglutamine ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Homo sapiens