Title : Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes.

Pub. Date : 2006 Mar 24

PMID : 16460683






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Curcumin increased HO-1 and glutamyl cysteine ligase modulator (GCLM) expression and stimulated Nrf2 binding to the ARE. Curcumin heme oxygenase 1 Homo sapiens
2 Curcumin also rapidly stimulated PKC phosphorylation and Ro-31-8220, a pan-PKC inhibitor, decreased curcumin-induced GCLM and HO-1 mRNA expression and ARE binding. Curcumin heme oxygenase 1 Homo sapiens
3 Curcumin also rapidly stimulated PKC phosphorylation and Ro-31-8220, a pan-PKC inhibitor, decreased curcumin-induced GCLM and HO-1 mRNA expression and ARE binding. Curcumin heme oxygenase 1 Homo sapiens
4 Rottlerin (a PKC delta inhibitor) and PKC delta antisense oligonucleotides significantly inhibited curcumin-induced GCLM and HO-1 mRNA expression and ARE binding. Curcumin heme oxygenase 1 Homo sapiens