Title : Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles.

Pub. Date : 2006 Jun 1

PMID : 16458519






1 Functional Relationships(s)
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1 Using a CYP26A1 homology model (based on CYP3A4) template, docking experiments were performed with MOE with multiple hydrophobic interactions observed in addition to coordination between the triazole nitrogen and the haem transition metal. Nitrogen cytochrome P450 family 26 subfamily A member 1 Homo sapiens