Pub. Date : 1991 May
PMID : 1645587
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stimulatory effects of estrogen on gonadotropin-releasing hormone-induced phosphoinositide turnover in granulosa cells. | Phosphatidylinositols | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 2 | Gonadotropin-releasing hormone (Gn-RH) stimulates phosphoinositide metabolism in granulosa cells by binding to its specific receptor, and suppresses gonadotropin-induced steroidogenesis. | Phosphatidylinositols | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 3 | Gonadotropin-releasing hormone (Gn-RH) stimulates phosphoinositide metabolism in granulosa cells by binding to its specific receptor, and suppresses gonadotropin-induced steroidogenesis. | Phosphatidylinositols | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 4 | Incubation of immature rat granulosa cells with Gn-RH stimulated time-sequential [32P]phosphate incorporation into phosphatidic acid (PA) and phosphatidylinositol (PI) in a dose-dependent manner; EC50 was at 10 nM. | Phosphatidylinositols | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 5 | In cells preincubated with E2 for 48 h, Gn-RH provoked a 7-fold [32P]phosphate incorporation into PI, suggesting the induction by E2 of Gn-RH-responsible phosphoinositide turnover. | Phosphatidylinositols | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 6 | In cells preincubated with E2 for 48 h, Gn-RH provoked a 7-fold [32P]phosphate incorporation into PI, suggesting the induction by E2 of Gn-RH-responsible phosphoinositide turnover. | Phosphatidylinositols | gonadotropin releasing hormone 1 | Rattus norvegicus |