Title : Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target.

Pub. Date : 2006 Feb 14

PMID : 16455797






2 Functional Relationships(s)
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1 We have expressed human SSAT from the cloned cDNA in Escherichia coli and have determined high-resolution structures of wild-type and mutant SSAT, as the free dimer and in binary and ternary complexes with CoA, acetyl-CoA (AcCoA), spermine, and the inhibitor N1,N11bis-(ethyl)-norspermine (BE-3-3-3). Acetyl Coenzyme A spermidine/spermine N1-acetyltransferase 1 Homo sapiens
2 We have expressed human SSAT from the cloned cDNA in Escherichia coli and have determined high-resolution structures of wild-type and mutant SSAT, as the free dimer and in binary and ternary complexes with CoA, acetyl-CoA (AcCoA), spermine, and the inhibitor N1,N11bis-(ethyl)-norspermine (BE-3-3-3). Acetyl Coenzyme A spermidine/spermine N1-acetyltransferase 1 Homo sapiens