Title : Pregnancy-enhanced endothelial nitric oxide synthase (eNOS) activation in uterine artery endothelial cells shows altered sensitivity to Ca2+, U0126, and wortmannin but not LY294002--evidence that pregnancy adaptation of eNOS activation occurs at multiple levels of cell signaling.

Pub. Date : 2006 May

PMID : 16455784






1 Functional Relationships(s)
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1 We report that pregnancy adaptation of eNOS activation includes the reduced sensitivity to ERK-mediated attenuation of eNOS activity and enhanced stimulation of eNOS activity through a wortmannin-sensitive, LY294002-insensitive, Akt-independent mechanism. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one nitric oxide synthase 3 Homo sapiens