Title : GSK-3 is activated by the tyrosine kinase Pyk2 during LPA1-mediated neurite retraction.

Pub. Date : 2006 Apr

PMID : 16452634






1 Functional Relationships(s)
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1 Using neuronal cells expressing the LPA(1) receptor, we show that LPA(1) mediates tyrosine phosphorylation and activation of GSK-3 with subsequent phosphorylation of the microtubule-associated protein tau via the G(i)-linked PIP(2) hydrolysis-Ca(2+) mobilization pathway. Tyrosine microtubule associated protein tau Homo sapiens