Pub. Date : 2006 May
PMID : 16447264
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show here that arsenite is a ubiquitous inducer of the heat shock response in mammalian cells: that it activated heat shock transcription factor 1 (HSF1) DNA-binding activity, enhanced hsp 70 promoter, and induced hsp70mRNA and synthesis of HSP chaperones. | arsenite | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 2 | We show here that arsenite is a ubiquitous inducer of the heat shock response in mammalian cells: that it activated heat shock transcription factor 1 (HSF1) DNA-binding activity, enhanced hsp 70 promoter, and induced hsp70mRNA and synthesis of HSP chaperones. | arsenite | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 3 | Using a high throughput hsp70 promoter-luciferase reporter assay, we observed a hormetic dose response where low concentrations of arsenite stimulated and high concentrations inhibited. | arsenite | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 4 | The effect of arsenite in inducing the hsp 70-luciferase reporter absolutely required a functional HSF1 as it was not observed in HSF1 minus cells but re-instated by expression of HSF1. | arsenite | heat shock protein family A (Hsp70) member 4 | Homo sapiens |