Pub. Date : 2006 Mar
PMID : 16447051
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pioglitazone, an in vitro inhibitor of CYP2C8 and CYP3A4, does not increase the plasma concentrations of the CYP2C8 and CYP3A4 substrate repaglinide. | Pioglitazone | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 2 | OBJECTIVE: Pioglitazone, a thiazolidinedione antidiabetic, inhibits cytochrome P450 (CYP) 2C8 and CYP3A4 enzymes in vitro. | Pioglitazone | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 3 | CONCLUSIONS: Pioglitazone does not increase the plasma concentrations of repaglinide, indicating that the inhibitory effect of pioglitazone on CYP2C8 and CYP3A4 is very weak in vivo, probably due to its extensive plasma protein binding. | Pioglitazone | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |